Reacción #1568555

Ecuación de reacción

5-bromo-1-methylpyridin-2(1H)-one

Tributylvinyltin

→

1-methyl-5-vinylpyridin-2(1H)-one

Disolventes

1,4-dioxane

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe title compound was prepared
2. 2
   workup.STIRRINGstirred at 100-105° C. for 2 h
3. 3
   OtroAfter completion of the starting material, the solvent was evaporated
4. 4
   Otrothe residue purified by column chromatography

Procedimiento

The title compound was prepared by following general procedure 2. To a solution of 5-bromo-1-methylpyridin-2(1H)-one (2 g, 10.63 mmol) in 20 mL of 1,4-dioxane, dichlorobis(triphenylphosphine)palladium(II) (0.834 g, 1.19 mmol) was added at RT and stirred at the same temperature for 5 min. Tributylvinyltin (3.46 mL, 1.19 mmol) was added slowly at RT and stirred at 100-105° C. for 2 h. The reaction was monitored by TLC and LCMS. After completion of the starting material, the solvent was evaporated and the residue purified by column chromatography using 60% ethyl acetate-hexane to afford 1.2 g of 1-methyl-5-vinylpyridin-2(1H)-one.

Fuente