Reacción #156624

Ecuación de reacción

2-[(S)-4-(2,7-diaza-spiro[4.4]non-2-yl)-phenyl]-6-hydroxy-3,4-dihydro-2H-isoquinolin-1-one

1-bromo-3-fluoro-propane

sodium hydrogencarbonate

NMP

→

2-{4-[(S)-7-(3-Fluoro-propyl)-2,7-diaza-spiro[4.4]non-2-yl]-phenyl}-6-hydroxy-3,4-dihydro-2H-isoquinolin-1-one

Disolventes

ethyl acetate

water

Condiciones de reacción

Tratamiento posterior

1. 1
   SecadoThe organic phase was dried over magnesium sulfate
2. 2
   Concentraciónconcentrated
3. 3
   OtroThe raw product was purified by preparative HPLC
4. 4
   OtroIn this way the product was obtained with molecular weight 423.54 (C25H30FN3O2)

Procedimiento

A mixture of 2-[(S)-4-(2,7-diaza-spiro[4.4]non-2-yl)-phenyl]-6-hydroxy-3,4-dihydro-2H-isoquinolin-1-one (0.20 g), 1-bromo-3-fluoro-propane (76 mg), sodium hydrogencarbonate (10 mg) and NMP (5 mL) was heated at 50° C. for 15 hours. The reaction mixture was distributed between ethyl acetate and water. The organic phase was dried over magnesium sulfate and concentrated. The raw product was purified by preparative HPLC. In this way the product was obtained with molecular weight 423.54 (C25H30FN3O2); MS (ESI): 424 (M+H+).

Fuente