Reacción #156609

ord-f20b44f76d09419c9373313e65a961cf

Ecuación de reacción

Cc1cc(Br)sc1C=O
5-Bromo-3-methylthiophene-2-carbaldehyde
Cc1ccc(B(O)O)cc1
4-methylphenylboronic acid
Cc1ccc(-c2cc(C)c(C=O)s2)cc1
3-Methyl-5-p-tolylthiophene-2-carbaldehyde

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    OtroThe product with the molecular weight of 216.30 (C13H12OS) was obtained in this way

Procedimiento

5-Bromo-3-methylthiophene-2-carbaldehyde (Spinelli, D. et al., J. Chem. Soc. Perkin Trans. 2, 1972, (12), 1866-9) was reacted with 4-methylphenylboronic acid by method J. The product with the molecular weight of 216.30 (C13H12OS) was obtained in this way; MS (ESI): 217 (M+H+).

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US08822495B2uspto-grants-2014_09