Reacción #156597

ord-7c25152f79be422db78328987bc7d3ed

Ecuación de reacción

CN(C)[C@@H]1CCN(c2ccc(N3CCc4cc(OS(=O)(=O)C(F)(F)F)ccc4C3=O)cc2F)C1
Trifluoromethanesulfonic acid 2-[4-((R)-3-dimethylaminopyrrolidin-1-yl)-3-fluorophenyl]-1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl ester
COC1CCNCC1
4-methoxypiperidine
→
COC1CCN(c2ccc3c(c2)CCN(c2ccc(N4CC[C@@H](N(C)C)C4)c(F)c2)C3=O)CC1
2-[4-((R)-3-Dimethylaminopyrrolidin-1-yl)-3-fluorophenyl]-6-(4-methoxypiperidin-1-yl)-3,4-dihydro-2H-isoquinolin-1-one

Reactantes

CN(C)[C@@H]1CCN(c2ccc(N3CCc4cc(OS(=O)(=O)C(F)(F)F)ccc4C3=O)cc2F)C1
Trifluoromethanesulfonic acid 2-[4-((R)-3-dimethylaminopyrrolidin-1-yl)-3-fluorophenyl]-1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl ester
COC1CCNCC1
4-methoxypiperidine

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    OtroThe product with the molecular weight of 466.60 (C27H35FN4O2) was obtained in this way

Procedimiento

Trifluoromethanesulfonic acid 2-[4-((R)-3-dimethylaminopyrrolidin-1-yl)-3-fluorophenyl]-1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl ester was reacted with 4-methoxypiperidine by method N. The product with the molecular weight of 466.60 (C27H35FN4O2) was obtained in this way; MS (ESI): 467 (M+H+).

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US08822495B2uspto-grants-2014_09