Reacción #156591

ord-69de3f758ca34cd18c6b024b8196e36a

Ecuación de reacción

CCCCOc1ccc(C(=O)Cl)c(CCCl)c1
4-Butoxy-2-(2-chloroethyl)benzoyl chloride
CC(C)(C)OC(=O)NC[C@H]1CCN(c2ccc(N)cc2F)C1
[(R)-1-(4-amino-2-fluorophenyl)pyrrolidin-3-yl]methylcarbamic acid tert-butyl ester
→
CCCCOc1ccc2c(c1)CCN(c1ccc(N3CC[C@H](CNC(=O)OC(C)(C)C)C3)c(F)c1)C2=O
{(R)-1-[4-(6-Butoxy-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-2-fluorophenyl]pyrrolidin-3-yl}methylcarbamic acid tert-butyl ester

Reactantes

CCCCOc1ccc(C(=O)Cl)c(CCCl)c1
4-Butoxy-2-(2-chloroethyl)benzoyl chloride
CC(C)(C)OC(=O)NC[C@H]1CCN(c2ccc(N)cc2F)C1
[(R)-1-(4-amino-2-fluorophenyl)pyrrolidin-3-yl]methylcarbamic acid tert-butyl ester

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    OtroThe product with the molecular weight of 511.64 (C29H38FN3O4) was obtained in this way

Procedimiento

4-Butoxy-2-(2-chloroethyl)benzoyl chloride was reacted by method A with [(R)-1-(4-amino-2-fluorophenyl)pyrrolidin-3-yl]methylcarbamic acid tert-butyl ester. The product with the molecular weight of 511.64 (C29H38FN3O4) was obtained in this way; MS (ESI): 512 (M+H+).

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US08822495B2uspto-grants-2014_09