Reacción #1563934

Ecuación de reacción

NaBH4

5-(2,5-difluorophenyl)-3,4-dihydro-2H-pyrrole

→

title compound

Rendimiento 79.8%

2-(2,5-difluorophenyl)pyrrolidine

Rendimiento 79.8%

Disolventes

MeOH H2O

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe reaction mixture was quenched with 1N aqueous HCl solution
2. 2
   Extracciónextracted with DCM
3. 3
   Secadodried over anhydrous sodium sulphate
4. 4
   Concentraciónconcentrated under reduced pressure

Procedimiento

NaBH4 (12 g, 314.9 mmol) was added to a solution of 5-(2,5-difluorophenyl)-3,4-dihydro-2H-pyrrole (28.5 g, 157.4 mmol) in a mixture of MeOH:H2O (4:1, 250 mL) and stirring was continued at 25-35° C. for 2 h. The reaction mixture was quenched with 1N aqueous HCl solution and basified with 2N aqueous NaOH solution, extracted with DCM, dried over anhydrous sodium sulphate and concentrated under reduced pressure to afford 23 g of the title compound.

Fuente