Reacción #1563907

Ecuación de reacción

NaHCO3

3,4-(Methylenedioxy)aniline

Ac2O

→

N-(benzo[d][1,3]dioxol-5-yl)acetamide

Rendimiento 95.0%

Disolventes

AcOH

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroAfter reaction
2. 2
   Filtraciónfiltered
3. 3
   ExtracciónThe filtrate was extracted with ethyl acetate

Procedimiento

To a solution of 3,4-(Methylenedioxy)aniline (8 g, 58.3 mmol) in AcOH (120 ml) was added Ac2O (48 mL). The mixture was stirred for overnight. After reaction, the mixture was poured into saturated NaHCO3 solution, and then filtered. The filtrate was extracted with ethyl acetate to give N-(benzo[d][1,3]dioxol-5-yl)acetamide (10 g, 95%). LCMS: 180[M+1]+; 1H NMR (DMSO-d6) δ 2.0 (s, 3H), 5.96 (s, 2H), 6.82 (d, 1H, J=8.1 Hz), 6.91 (d, 1H, J=2.1 Hz), 7.30 (d, 1H, J=1.8 Hz), 9.84 (s, 1H).

Fuente