Reacción #155402

Ecuación de reacción

Boc2O

3-methylene-cyclobutane carboxylic acid

NaN3

→

N-Boc-3-methylene-cyclobutanamine

Rendimiento 34.9%

Disolventes

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturawas heated at 45° C. overnight
2. 2
   TemperaturaThe reaction was then cooled to 0° C.
3. 3
   Otrowas quenched with 10% aq. NaNO2 (180 mL)
4. 4
   OtroThe THF was evaporated
5. 5
   Extracciónthe aqueous layer was extracted with EtOAc (180 mL)
6. 6
   LavadoThe organic layer was washed with 5% aq. NaHCO3 (2×20 mL), brine (30 ml)
7. 7
   Secadodried over Na2SO4
8. 8
   Filtraciónfiltered
9. 9
   Concentraciónconcentrated to dryness
10. 10
    Otroto yield a crude, which
11. 11
    Otrowas purified by flash chromatography (silica gel/hexanes:ethyl acetate: 0-90%)

Procedimiento

To a stirring solution of 3-methylene-cyclobutane carboxylic acid (1.0 g, 8.9 mmol) in THF (90 mL) was added NaN3 (2.0 g, 31.1 mmol), followed by tetrabutyl ammonium bromide (0.48 g, 1.5 mmol) and Zn(OTf)2 (0.1 g, 0.3 mmol), and the reaction mixture was heated to 40° C. Boc2O (2.1 g, 9.8 mmol) was then added at once, and the reaction was heated at 45° C. overnight. The reaction was then cooled to 0° C. and was quenched with 10% aq. NaNO2 (180 mL). The THF was evaporated and the aqueous layer was extracted with EtOAc (180 mL). The organic layer was washed with 5% aq. NaHCO3 (2×20 mL), brine (30 ml), dried over Na2SO4, filtered and concentrated to dryness to yield a crude, which was purified by flash chromatography (silica gel/hexanes:ethyl acetate: 0-90%) to yield the desired N-Boc-3-methylene-cyclobutanamine (0.57 g, 3.1 mmol, 34.9% yield): 1H NMR (250 MHz, CDCl3) δ 4.83 (s, 2H), 4.79 (bs, 1H), 4.05-4.23 (m, 1H), 2.92-3.11 (m, 2H), 2.50-2.65 (m, 2H), 1.44 (s, 9H).

Fuente