Reacción #155397

Ecuación de reacción

HCl

2-chloro-4-(methylsulfonyl)benzoyl chloride

5-amino-1-(2-methoxyethyl)tetrazole

water

→

2-chloro-4-(methylsulfonyl)-N-(1-(2-methoxyethyl)tetrazol-5-yl)-benzamide

Disolventes

EA

pyridine

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe organic phase is separated off
2. 2
   Lavadowashed with 2N HCl and brine
3. 3
   Secadodried over Na2SO4
4. 4
   Concentraciónconcentrated
5. 5
   Otropurified by RP—HPLC (acetonitrile/water)

Procedimiento

176 mg (0.75 mmol) of 2-chloro-4-(methylsulfonyl)benzoyl chloride, 145 mg (1.0 mmol) of 5-amino-1-(2-methoxyethyl)tetrazole in 2 ml of pyridine are stirred at 60° C. for 12 h. 0.1 ml of water is then added, the mixture is stirred at 60° C. for 30 min and EA and 2N HCl are added. The organic phase is separated off and washed with 2N HCl and brine, dried over Na2SO4, concentrated and purified by RP—HPLC (acetonitrile/water). Yield 66 mg (23%).

Fuente