Reacción #155341

Ecuación de reacción

Lithium hydroxide mono-hydrate

water

methyl 3-{2-[5-fluoro-3-(4-methoxyphenyl)-4-oxo-8-propoxy-4H-quinolin-1-yl]ethylsulfanyl}propionate

→

3-{2-[5-fluoro-3-(4-methoxyphenyl)-4-oxo-8-propoxy-4H-quinolin-1-yl]ethylsulfanyl}propionic acid

Rendimiento 82.3%

Disolventes

acetonitrile

Condiciones de reacción

Tratamiento posterior

1. 1
   LavadoThe reaction mixture was washed with ethyl acetate
2. 2
   workup.ADDITION2N hydrochloric acid was added to the water layer
3. 3
   OtroThe generated insoluble matter was separated
4. 4
   Lavadowashed with water
5. 5
   Otrodried

Procedimiento

Lithium hydroxide mono-hydrate (31 mg, 0.74 mmol) and water (5 ml) were added to an acetonitrile solution (10 ml) of methyl 3-{2-[5-fluoro-3-(4-methoxyphenyl)-4-oxo-8-propoxy-4H-quinolin-1-yl]ethylsulfanyl}propionate (175 mg, 0.37 mmol), and the mixture was stirred at room temperature for 2 hours. The reaction mixture was washed with ethyl acetate, and then 2N hydrochloric acid was added to the water layer to make the mixture acidic. The generated insoluble matter was separated, washed with water and then dried, giving a white powder of 3-{2-[5-fluoro-3-(4-methoxyphenyl)-4-oxo-8-propoxy-4H-quinolin-1-yl]ethylsulfanyl}propionic acid (140 mg, yield: 82%).

Fuente