Reacción #155319

Ecuación de reacción

5-Methylbenzofuran-7-ylamine

ethanol

→

5-methyl-2,3-dihydrobenzofuran-7-ylamine

Rendimiento 87.6%

Disolventes

dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrofollowed by conduction of catalytic reduction at room temperature under ordinary pressure
2. 2
   OtroThe catalyst was removed by celite filtration
3. 3
   Otrocondensed under reduced pressure
4. 4
   Secadodried over anhydrous magnesium sulfate
5. 5
   Concentraciónconcentrated to dryness under reduced pressure

Procedimiento

5-Methylbenzofuran-7-ylamine (1.3 g, 8.8 mmol) and 10% palladium carbon (500 mg) were added to ethanol (50 ml), followed by conduction of catalytic reduction at room temperature under ordinary pressure. The catalyst was removed by celite filtration, and the obtained filtrate was condensed under reduced pressure. The residue was dissolved in dichloromethane, dried over anhydrous magnesium sulfate, and then concentrated to dryness under reduced pressure, giving a white powder of 5-methyl-2,3-dihydrobenzofuran-7-ylamine (1.15 g, yield: 87%).

Fuente