Reacción #1545871

Ecuación de reacción

Methyl 4-nitrophenoxyacetate

→

brown oil

Rendimiento 94.3%

Methyl 4-aminophenoxyacetate

Rendimiento 94.3%

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe reactor was purged with nitrogen gas
2. 2
   OtroAfter completion of the reaction
3. 3
   Otrothe reactor was purged again with nitrogen gas
4. 4
   FiltraciónThe Pd/C was filtered off
5. 5
   workup.DISTILLATIONthe solvent was then distilled out under reduced pressure

Procedimiento

Methyl 4-nitrophenoxyacetate (5.0 g; 24 mmol) was dissolved in 150 ml of methanol in a reactor, followed by the addition of 480 mg of 5% Pd/C. The reactor was purged with nitrogen gas. Under a hydrogen gas atmosphere, the resultant mixture was stirred at room temperature for 2 hours. After completion of the reaction, the reactor was purged again with nitrogen gas. The Pd/C was filtered off and the solvent was then distilled out under reduced pressure, whereby 4.1 g of a brown oil were obtained (yield: 92%).

Fuente