Reacción #1541933

Ecuación de reacción

potassium

3-oxo-2-cyanopropanoic acid ethyl ester

triphenylsulfonium chloride

→

desired product

3-oxo-2-cyanopropanoic acid ethyl ester triphenylsulfonium salt

Disolventes

Water

water

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónthe mixture was extracted with chloroform (2×25 ml)
2. 2
   Secadoby drying over MgSO4
3. 3
   OtroThe removal of the solvent
4. 4
   Otroon a rotary evaporator under reduced pressure

Procedimiento

Into a solution of potassium salt of 3-oxo-2-cyanopropanoic acid ethyl ester (1.79 g, 10 mmol) in water (10 ml) was added a 50% solution of triphenylsulfonium chloride in water (5.96 g, 10 mmol). The reaction mixture turned cloudy. Water (15 ml) was added and the mixture was extracted with chloroform (2×25 ml) followed by drying over MgSO4. The removal of the solvent on a rotary evaporator under reduced pressure gave desired product as yellow crystalline material. Yield 3.2 g (80%).

Fuente