Reacción #1526987

Ecuación de reacción

7-(3(R)-hydroxy-5-oxocyclopent-1-en-1-yl)heptanoic acid

benzene

p-toluenesulfonic acid

dihydropyran

→

tetrahydropyran-2-yl 7-(3(R)-tetrahydropyran-2-yloxy-5-oxocyclopent-1-en-1-yl)-heptanoate

Disolventes

ethyl acetate

Condiciones de reacción

Tratamiento posterior

1. 1
   Lavadowashed with water
2. 2
   Secadodried over anhydrous sodium sulfate

Procedimiento

To a solution of 1.70 parts of 7-(3(R)-hydroxy-5-oxocyclopent-1-en-1-yl)heptanoic acid in 12 parts by volume of dry benzene is added 0.005 part of p-toluenesulfonic acid and 3.40 parts of dihydropyran. The reaction mixture is allowed to stand at room temperature for about 24 hours. The resulting solution is diluted with ethyl acetate, washed with water, dried over anhydrous sodium sulfate, and stripped of solvent under reduced pressure to afford tetrahydropyran-2-yl 7-(3(R)-tetrahydropyran-2-yloxy-5-oxocyclopent-1-en-1-yl)-heptanoate. This compound is represented by the following structural formula. ##STR21##

Fuente