Reacción #1524

Ecuación de reacción

4-hydroxymethyl-4'-decyloxybiphenyl

HBr

→

4'-bromomethyl-4-decyloxybiphenyl

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroAfter completion of the reaction
2. 2
   Extracciónthe resultant mixture was extracted with ether
3. 3
   Lavadowashed with water, which
4. 4
   Lavadowas further washed with an aqueous solution
5. 5
   workup.ADDITIONcontaining saturated NaHCO3
6. 6
   Lavadowashed again with water
7. 7
   ConcentraciónThe reaction product was concentrated
8. 8
   Otroseparated by colomun chromatography

Procedimiento

To 0.81 g (2.51 mmol) of 4-hydroxymethyl-4'-decyloxybiphenyl was added 15 ml of an aqueous solution containing 47% HBr, and then healed at 115° C. for 3 hours. After completion of the reaction, the resultant mixture was extracted with ether and washed with water, which was further washed with an aqueous solution containing saturated NaHCO3 and washed again with water. The reaction product was concentrated and, then, separated by colomun chromatography, to thereby obtain 0.92 g of 4'-bromomethyl-4-decyloxybiphenyl.

Fuente