Reacción #1519120

Ecuación de reacción

Z-L-Pro-OH

thionyl chloride

→

Z-L-Pro-Cl

Disolventes

DCM

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturais heated
2. 2
   Temperaturato reflux under nitrogen for 20 minutes
3. 3
   Concentraciónconcentrated in vacuo
4. 4
   Concentraciónconcentrated

Procedimiento

A mixture of Z-L-Pro-OH E-1 (10.0 g, 40.1 mmol, 1 equiv.) and thionyl chloride (30 mL, 401.2 mmol, 10 equiv.) in DCM (200 mL) is heated to reflux under nitrogen for 20 minutes and concentrated in vacuo. The residual oil is coevaporated with toluene 3×, and concentrated to give Z-L-Pro-Cl as an opaque oil.

Fuente