Reacción #1519118

Ecuación de reacción

(2S,3R)-3-(n-butyl)-2-hydroxysuccinic acid

p-TSA

→

2-(2,2-dimethyl-4-oxo-1,3-dioxolan-5-yl)hexanoic acid

Disolventes

DCM

2,2-dimethoxypropane

Condiciones de reacción

Tratamiento posterior

1. 1
   Lavadowashed with brine
2. 2
   Secadodried (Na2SO4)
3. 3
   Otropurified by silica gel chromatography

Procedimiento

To a solution of (2S,3R)-3-(n-butyl)-2-hydroxysuccinic acid B-4 (300 mg, 1.58 mmol) in 2,2-dimethoxypropane (10 mL) is added p-TSA (20 mg) and the reaction is stirred at rt for 16 hours. The solution is diluted with DCM and washed with brine, dried (Na2SO4) and then purified by silica gel chromatography to afford 1.2 mmol 2-(2,2-dimethyl-4-oxo-1,3-dioxolan-5-yl)hexanoic acid B-5.

Fuente