Reacción #1519117

Ecuación de reacción

(2S,3R)-3-(n-butyl)-2-hydroxysuccinic dimethyl ester

NaOH

HCl

→

(2S,3R)-3-(n-butyl)-2-hydroxysuccinic acid

Disolventes

MeOH

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe MeOH is removed
2. 2
   Otrothe crude reaction
3. 3
   Extracciónextracted with EtOAc (3×50 mL)
4. 4
   SecadoThe combined organic layers are dried (Na2SO4)
5. 5
   Concentraciónconcentrated

Procedimiento

To (2S,3R)-3-(n-butyl)-2-hydroxysuccinic dimethyl ester B-3 in MeOH (28 mL) is added a solution of NaOH (2.2 g, 55 mmol) in water (28 mL). After 24 hours, the MeOH is removed, the crude reaction is acidified with HCl (6 N, 12 mL) to pH=1, and then extracted with EtOAc (3×50 mL). The combined organic layers are dried (Na2SO4) and concentrated to give (2S,3R)-3-(n-butyl)-2-hydroxysuccinic acid B-4.

Fuente