Reacción #1518116

Ecuación de reacción

5-nitro-1H-indazole

NIS

→

3-iodo-5-nitro-1H-indazole

Rendimiento 96.0%

Disolventes

EtOAc

DMF

Condiciones de reacción

Tratamiento posterior

1. 1
   Lavadowashed with sat'd sodium bisulfite solution, water
2. 2
   SecadoThe organic layer was dried over Na2SO4
3. 3
   Filtraciónfiltered
4. 4
   Concentraciónconcentrated

Procedimiento

5-nitro-1H-indazole (2 g, 12.26 mmol) was taken up in DMF (40 mL) and NIS (5.52 g, 24.52 mmol) was added. The reaction was stirred at rt for 72 h. The reaction mixture was diluted with EtOAc and washed with sat'd sodium bisulfite solution, water, and then 2× with brine. The organic layer was dried over Na2SO4, filtered and concentrated to give 3-iodo-5-nitro-1H-indazole (3.4 g) as a yellow solid.

Fuente