Reacción #1509597

Ecuación de reacción

dimethylamine

2-Chloro-6-methyl-isonicotinic acid

DIPEA

TBTU

→

title compound

2-Chloro-6,N,N-trimethyl-isonicotinamide

Disolventes

water

DMF

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónextracted with EtOAc
2. 2
   OtroThe organic layer was separated
3. 3
   Otrodried
4. 4
   Concentraciónconcentrated in vacuum

Procedimiento

To a solution of 2-Chloro-6-methyl-isonicotinic acid (1 g) in DMF (200 ml) at 25° C. was added DIPEA (2.9 mL) and TBTU (1.8 ml). After 5 min, dimethylamine (0.75 g) was added dropwise. This was stirred overnight. The reaction was added to water and extracted with EtOAc. The organic layer was separated, dried and concentrated in vacuum. Flash:chromatography (9:1 to 2:8 gradient cyclohexane:EtOAc) afforded the title compound (320 mg). Rf=0.56 (1:1 cyclohexane:EtOAc)

Fuente