Reacción #1509588

Ecuación de reacción

Methyl 3-(tert.-butoxycarbonylamino)-5-tert-butylbenzoate

TFA

→

ethyl 3-amino-5-tert-butylbenzoate

Disolventes

DCM

Condiciones de reacción

Tratamiento posterior

1. 1
   Concentraciónconcentrated in vacuum
2. 2
   workup.DISSOLUTIONThe residue was dissolved in DCM
3. 3
   Extracciónextracted with aqueous sodium bicarbonate solution
4. 4
   OtroThe organic layer was separated
5. 5
   Secadodried over sodium sulphate
6. 6
   Concentraciónconcentrated in vacuum

Procedimiento

Methyl 3-(tert.-butoxycarbonylamino)-5-tert-butylbenzoate (0.42 g) was dissolved in DCM (5 ml). To the resulting solution, TFA (1 ml) was added, the mixture was stirred for 30 min at room temperature and then concentrated in vacuum. The residue was dissolved in DCM and extracted with aqueous sodium bicarbonate solution. The organic layer was separated, dried over sodium sulphate and concentrated in vacuum to yield ethyl 3-amino-5-tert-butylbenzoate (0.28 g), which was used for the synthesis of example 112 without further purification.

Fuente