Reacción #1509580

Ecuación de reacción

thiourea

Ethyl 2-bromo-4-methyl-3-oxopentanoate

→

product

Rendimiento 40.6%

Ethyl 2-amino-4-isopropylthiazole-5-carboxylate

Rendimiento 40.6%

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturato reflux
2. 2
   Temperaturathe reaction mixture refluxed further for 1 h
3. 3
   Concentraciónwas concentrated in vacuum

Procedimiento

A solution of thiourea (1.1 g) in ethanol (10 mL) was brought to reflux. Ethyl 2-bromo-4-methyl-3-oxopentanoate (3.0 g) was then added and the reaction mixture refluxed further for 1 h. The reaction was complete (by TLC) and was concentrated in vacuum. Flash chromatography (100% DCM→90:10 DCM:MeOH) afforded the product (1.1 g).

Fuente