Reacción #1504301

Ecuación de reacción

benzyl bromide

2-(2-amino-ethoxy)-ethanol

potassium carbonate

water

→

1-Dibenzylamino-5-hydroxy-3-oxapentane

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturarefluxed for 2 hours
2. 2
   ConcentraciónIt is concentrated by evaporation in a vacuum
3. 3
   Filtraciónfiltered off from the salts
4. 4
   ConcentraciónThe filtrate is concentrated by evaporation in a vacuum
5. 5
   Otropurified by flash chromatography on silica gel

Procedimiento

A mixture of 50 g (475.56 mmol) of 2-(2-amino-ethoxy)-ethanol and 144.6 g (1.046 mol) of potassium carbonate in 600 ml of ethanol/60 ml of water is heated to 60° C. 178.95 g (1.046 mol) of benzyl bromide is instilled in this mixture within 1 hour and then refluxed for 2 hours. It is concentrated by evaporation in a vacuum, the residue is taken up with 1 l of dichloromethane and filtered off from the salts. The filtrate is concentrated by evaporation in a vacuum and purified by flash chromatography on silica gel. (Mobile solvent: dichloromethane/hexane/acetone: 10/5/1)

Fuente