Reacción #1504299

Ecuación de reacción

p-chlorophenol

pyridine

toluene

propionic acid chloride

→

propionic acid-p-chlorophenyl ester

Rendimiento 89.0%

Disolventes

Water

Condiciones de reacción

Tratamiento posterior

1. 1
   ConcentraciónThe organic layer was concentrated anddistilled under reduced pressure (bp. 73°-76° C./0.2 mmHg)

Procedimiento

Into a mixture of p-chlorophenol (20.0 g, 156 mmol), pyridine (14.8 g, 187 mmol), and toluene (150 ml), propionic acid chloride (17.3 g, 187 mmol) was addeddropwise, and the resultant mixture was stirred for 1 hour at room temperature. Water (150 ml) was added and the aqueous layer was discarded. The organic layer was concentrated anddistilled under reduced pressure (bp. 73°-76° C./0.2 mmHg), thereby obtaining a propionic acid-p-chlorophenyl ester (25.6 g, 138 mmol, 89%).

Fuente