Reacción #1502

Ecuación de reacción

Chloromethyl chloroformate

cholesterol

Pyridine

→

3-(Chloromethoxycarbonyl) Cholesterol

Disolventes

CH2Cl2

CH2Cl2

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe solution was cooled
2. 2
   TemperaturaHeat
3. 3
   Otrowas produced
4. 4
   Otrothe reaction gave a clear solution from
5. 5
   Lavadowashed with 0.5M HCl (50 ml) and water (3×25 ml)
6. 6
   OtroAfter treatment with MgSO4, the solution was evaporated to dryness

Procedimiento

Chloromethyl chloroformate (1.96 g, 15.2 mmol) and cholesterol (5.0 g, 12.9 mmol) was dissolved in CH2Cl2 (10 ml). The solution was cooled. Pyridine (1.21 g, 15.3 mmol) was dripped into the stirred solution over 5 minutes. Heat was produced and the reaction gave a clear solution from a somewhat unclear starting solution. After 24 hours at room temperature, the mixture was diluted with CH2Cl2 (50 ml), washed with 0.5M HCl (50 ml) and water (3×25 ml). After treatment with MgSO4, the solution was evaporated to dryness.

Fuente