Reacción #1487970

Ecuación de reacción

NaBH4

3,5-dibromosalicylaldehyde

NaBH4

→

2-hydroxy-3,5-dibromobenzenemethanol

Rendimiento 94.0%

Disolventes

MeOH

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.STIRRINGthe mixture was stirred for another 2 hours
2. 2
   OtroThe solvent was removed under vacuum
3. 3
   Otrothe resulting white solid was re-precipitated in water
4. 4
   FiltraciónThe product was collected as a white solid by vacuum filtration (10.1 grams, 94% yield)

Procedimiento

To a stirred solution of 3,5-dibromosalicylaldehyde (10.6 grams, 38 mmol) in MeOH (70 mL), was added NaBH4 (4.3 grams, 115 mmol) in small portions and the solution was stirred for 1.5 hours. Another batch of NaBH4 (2.0 grams, 52 mmol) was added in small portions and the mixture was stirred for another 2 hours. The solvent was removed under vacuum and the resulting white solid was re-precipitated in water. The product was collected as a white solid by vacuum filtration (10.1 grams, 94% yield).

Fuente