Reacción #1478574

Ecuación de reacción

p-nitroaniline

calcium carbonate

chloroacetamide

→

pure product

Rendimiento 58.0%

2-(4-nitrophenylamino)acetamide

Rendimiento 58.0%

Disolventes

water ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturawas refluxed for 42 hours
2. 2
   FiltraciónThe resulting mixture was filtered while hot and
3. 3
   Temperaturato cool
4. 4
   Filtraciónthe crystals were filtered off by suction
5. 5
   Lavadowashed with absolute ethanol
6. 6
   OtroAfter drying
7. 7
   Otro87.9 g of crude product were obtained
8. 8
   OtroAfter two recrystallizations from acetonitrile

Procedimiento

A mixture of p-nitroaniline (55.2 g, 0.4 mol), calcium carbonate (80 g) and chloroacetamide (149.6 g, 1.6 mol) in 350 ml of water/ethanol (1/1) was refluxed for 42 hours. The resulting mixture was filtered while hot and allowed to cool, and the crystals were filtered off by suction, reslurried in water and then washed with absolute ethanol. After drying, 87.9 g of crude product were obtained. After two recrystallizations from acetonitrile, 45.3 g of pure product were obtained (melting point=178° C.).

Fuente