Reacción #1471362

Ecuación de reacción

suspension

6-(Aminocarbonyl)-2-naphthalenecarboxylic acid, methyl ester

water

→

title compound

Rendimiento 92.2%

6-Cyano-2-naphthalenecarboxylic acid, methyl ester

Rendimiento 92.2%

Disolventes

trimethyl phosphate

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaheated in an oil bath at 80° C. for 1 h
2. 2
   Temperaturawhile cooling to room temperature
3. 3
   Filtraciónfiltered
4. 4
   Lavadothe white solid was thoroughly washed with water
5. 5
   Otrodried under vacuum

Procedimiento

A suspension of Example 8C (31 g, 135 mmole) in trimethyl phosphate (450 mL) was treated with triphosgenie (27 g, 136 mmole), stirred for 20 min at room temperature and heated in an oil bath at 80° C. for 1 h. The product precipated from the solution while cooling to room temperature. The thick slutty was treated with water and filtered, and the white solid was thoroughly washed with water and dried under vacuum to provide 26.3 g of the title compound.

Fuente