Reacción #1470439

Ecuación de reacción

Succinic anhydride

2,6-diisopropylphenol

→

2,6-diisopropylphenyl hydrogen succinate

Rendimiento 80.2%

Disolventes

triethylamine

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrosolvents were removed under vacuum
2. 2
   workup.DISSOLUTIONThe residue was dissolved in water
3. 3
   workup.ADDITIONadded to an iced solution of dilute hydrochloric acid
4. 4
   FiltraciónThe precipitated product was filtered
5. 5
   Otrorecrystallized from ethanol-water

Procedimiento

Succinic anhydride (14 g, 140 mmol) and dimethylaminopyridine (0.02 g, 0.16 mmol) were added to a solution of 2,6-diisopropylphenol (20.8 ml, 112 mmol) in triethylamine (50 ml) under nitrogen. After 16 hr at room temperature, solvents were removed under vacuum. The residue was dissolved in water and added to an iced solution of dilute hydrochloric acid. The precipitated product was filtered and recrystallized from ethanol-water to yield 25.0 g (80.2% yield) of 2,6-diisopropylphenyl hydrogen succinate (propofol hemisuccinate), mp 101-102° C.

Fuente