Reacción #1470438

Ecuación de reacción

thionyl chloride

α-aminolauric acid

isopropanol

→

α-Aminolauric acid isopropyl ester

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturato reflux for two hours
2. 2
   TemperaturaAfter cooling off to room temperature
3. 3
   Concentraciónthe batch is completely concentrated by evaporation
4. 4
   workup.STIRRINGshaken out from aqueous sodium carbonate solution
5. 5
   OtroThe organic phase is dried on magnesium sulfate
6. 6
   Filtraciónfiltered
7. 7
   Concentraciónconcentrated by evaporation

Procedimiento

50 ml of isopropanol is stirred at 0° C. under argon and mixed drop by drop with 3.12 ml (41.6 mmol) of thionyl chloride. 30 minutes later, 7.40 g (34.4 mmol) of α-aminolauric acid is added in portions, stirred for one hour at room temperature and the batch then is allowed to reflux for two hours. After cooling off to room temperature, the batch is completely concentrated by evaporation, the residue is taken up in tert-butyl methyl ether and shaken out from aqueous sodium carbonate solution. The organic phase is dried on magnesium sulfate, filtered and concentrated by evaporation.

Fuente