Reacción #1469681

Ecuación de reacción

chloroacetylchloride

HCl

thionylchloride

hydrochloride

N-(-1-methoxyprop-2-yl)-2,4-dimethyl-3-aminothiophene

→

title compound

N-(2,4-Dimethylthien-3-yl)-N-(1-methoxyprop-2-yl)-chloroacetamide

Disolventes

cyclohexane ethyl acetate

toluene

toluene

toluene

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrois obtained
2. 2
   TemperaturaThis mixture is heated during 1 hour
3. 3
   Temperaturaat reflux

Procedimiento

0.02 Mol thionylchloride in 5 ml toluene are added dropwise, within 40 minutes, to 0.02 mol N-(1-methoxyprop-2-yl-)-2,4-dimethyltetrahydrothien-3-ylidenimine, dissolved in 10 ml of toluene at 20° . The reaction mixture is stirred for 2 hours whereby the hydrochloride of N-(-1-methoxyprop-2-yl)-2,4-dimethyl-3-aminothiophene is obtained. Then are added 0.02 mol of chloroacetylchloride dissolved in 5 ml toluene. This mixture is heated during 1 hour at reflux, whereby HCl escapes. The title compound is obtained by column chromatography on silica gel with cyclohexane/ethyl acetate (8:2), b.p. 148°-150°/0.03 Torr.

Fuente