Reacción #1458415

ord-1bc0273f6d9e4898b5a2d888224182f6

Ecuación de reacción

CC(=O)Oc1ccc(Cl)cc1
p-chlorophenyl acetate
C=C(C)OC(C)=O
isopropenyl acetate
CC(=O)O[C@H](C)c1ccccc1
(R)-1-phenylethyl acetate
Rendimiento 95.0%

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    Otroused in Example 1 over a reaction period of 42 hours

Procedimiento

The procedure of Example 1 was repeated except that 3 molar equivalents of p-chlorophenyl acetate (a conventional acylating agent) was used in place of isopropenyl acetate in the presence of three times the amount of the enzyme catalyst used in Example 1 over a reaction period of 42 hours, to obtain (R)-1-phenylethyl acetate having an optical purity of higher than 99%, at a yield of 95%.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07156731B2uspto-grants-2007_01