Reacción #1455203

Ecuación de reacción

3-[7-Chloro-5-fluoro-2(3H)benzoxazolinon-4-yl]-1-methyl-6-trifluoromethyl-2,4(1H,3H)-pyrimidinedione

methyl pyruvate

water

→

title compound

Rendimiento 43.0%

3-(8-Chloro-6-fluoro-3-methyl-2H-1,4-benzoxazin-2-one-5-yl)-1-methyl-6-trifluoromethyl-2,4(1H,3H)-pyrimidindione

Rendimiento 43.0%

Disolventes

toluene

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe solvent was then removed under reduced pressure
2. 2
   OtroThe residue was chromatographed on silica gel

Procedimiento

3-[7-Chloro-5-fluoro-2(3H)benzoxazolinon-4-yl]-1-methyl-6-trifluoromethyl-2,4(1H,3H)-pyrimidinedione (0.50 g) was dissolved in anhydrous toluene (15 ml) and methyl pyruvate (0.15 g) was added. The solution was refluxed with azeotropic removal of water for 2 hours and the solvent was then removed under reduced pressure. The residue was chromatographed on silica gel using hexane-ethyl acetate (3:1) as the eluent to afford the title compound (0.23 g).

Fuente