Reacción #1455200

Ecuación de reacción

7-chloro-2-ethyl-5-fluoro-4-nitrobenzoxazole

→

4-amino-7-chloro-2-ethyl-5-fluorobenzoxazole

Rendimiento 96.7%

Disolventes

ethyl acetate

hydrogen

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrowas bubbled through the suspension for 5 hours
2. 2
   FiltraciónAfter filtration and evaporation

Procedimiento

Step 5 Palladium on activated carbon (10%, 0.1 g) was added to a solution of 7-chloro-2-ethyl-5-fluoro-4-nitrobenzoxazole (0.86 g) in ethyl acetate (80 ml) and hydrogen was bubbled through the suspension for 5 hours. After filtration and evaporation, 4-amino-7-chloro-2-ethyl-5-fluorobenzoxazole(0.73 g) was obtained as the single product.

Fuente