Reacción #1447133

Ecuación de reacción

dimethylamine

2-bromo-1-(4-bromophenyl)ethanone

→

title compound

Rendimiento 86.0%

1-(4-Bromophenyl)-2-(dimethylamino)ethanone

Rendimiento 86.0%

Disolventes

methanol

tetrahydrofuran

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe solvent was removed by distillation
2. 2
   Otrothe residue was then purified by column chromatography on silica gel (hexane:ethyl acetate=10:1 to 0:100)

Procedimiento

A 2.0 M solution of dimethylamine (0.5 mmol) in methanol was added to a solution of 2-bromo-1-(4-bromophenyl)ethanone (114.5 mg, 0.41 mmol) in tetrahydrofuran (2 ml), and the mixture was stirred at room temperature for 15 min. The solvent was removed by distillation, and the residue was then purified by column chromatography on silica gel (hexane:ethyl acetate=10:1 to 0:100) to give 84.7 mg (yield 86%) of the title compound.

Fuente