Reacción #1447123

Ecuación de reacción

1-(2-aminophenyl)-3-methylbutan-1-one

hydrazine hydrate

water

potassium hydroxide

→

[2-(3-methylbutyl)-phenyl]amine

Rendimiento 72.1%

Disolventes

ethyl acetate

triethylene glycol

Condiciones de reacción

Tratamiento posterior

1. 1
   LavadoThe organic phase is again washed with water
2. 2
   Secadodried over magnesium sulphate
3. 3
   Concentraciónconcentrated under reduced pressure
4. 4
   OtroPurification by column chromatography (cyclohexane/ethyl acetate 3:1)

Procedimiento

A solution comprising 8.0 g (0.045 mol) of 1-(2-aminophenyl)-3-methylbutan-1-one (X-1), 6.8 g (0.135 mol) of hydrazine hydrate and 7.6 g (0.135 mol) of potassium hydroxide in 90 ml of triethylene glycol is heated at 210° C. for 6 h. For work-up, water and ethyl acetate are added at room temperature. The organic phase is again washed with water, dried over magnesium sulphate and concentrated under reduced pressure. Purification by column chromatography (cyclohexane/ethyl acetate 3:1) gives 5.3 g (71.5% of theory) of [2-(3-methylbutyl)-phenyl]amine.

Fuente