Reacción #1447117

ord-3ddd7d4e011440eb9d7c77cc15a78b39

Ecuación de reacción

O=P(Cl)(Cl)Oc1ccc(Cl)cc1
4-chlorophenyl dichlorophosphate
CCOC(=O)[C@H](C)N.Cl
L-alanine ethyl ester hydrochloride
CCN(CC)CC
Et3N
CCOC(=O)[C@H](C)NP(=O)(Cl)Oc1ccc(Cl)cc1
title compound
CCOC(=O)[C@H](C)NP(=O)(Cl)Oc1ccc(Cl)cc1
Ethyl N-[chloro(4-chlorophenoxy)phosphoryl]-L-alaninate

Disolventes

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

Following the procedure described for Example 1, step 2, treatment of a solution in DCM (0.090 M) of 4-chlorophenyl dichlorophosphate with L-alanine ethyl ester hydrochloride (1.0 eq.) and Et3N (2.0 eq.) provided the title compound as a colorless oil as a 1:1* mixture of diastereoisomers.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07879815B2uspto-grants-2011_02