Reacción #1447098

Ecuación de reacción

hydrochloric acid

N-[4-bromo-2-(4-ethyl-benzyl)-5-methoxy-phenyl]-acetamide

→

title compound

4-Bromo-2-(4-ethyl-benzyl)-5-methoxy-phenylamine

Disolventes

isopropanol

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe solution is heated
2. 2
   Temperaturaat reflux temperature for 8 h
3. 3
   Concentraciónconcentrated under reduced pressure
4. 4
   Otroto remove most of the alcohol
5. 5
   workup.ADDITIONAqueous NaHCO3 solution is added to the rest
6. 6
   Extracciónthe resulting mixture is extracted twice with ethyl acetate
7. 7
   LavadoThe combined organic extracts are washed with brine
8. 8
   Secadodried (Na2SO4)
9. 9
   Concentraciónconcentrated

Procedimiento

Half-concentrated hydrochloric acid (5 mL) is added to a solution of N-[4-bromo-2-(4-ethyl-benzyl)-5-methoxy-phenyl]-acetamide (2.8 g) in isopropanol (20 mL). The solution is heated at reflux temperature for 8 h and then concentrated under reduced pressure to remove most of the alcohol. Aqueous NaHCO3 solution is added to the rest and the resulting mixture is extracted twice with ethyl acetate. The combined organic extracts are washed with brine, dried (Na2SO4) and concentrated to give the title compound.

Fuente