Reacción #1444572

Ecuación de reacción

N-{2-[3,4-Bis-(1-benzyl-1H-tetrazol-5-yl)phenoxy]phenyl}acetamide

hydrochloric acid

→

2-[3,4-bis-(1-benzyl-1H-tetrazol-5-yl)phenoxy]phenylamine

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturathe reaction mixture was refluxed for 15 hours
2. 2
   OtroThe mixture was evaporated in vacuo
3. 3
   workup.DISSOLUTIONredissolved in methylene chloride
4. 4
   SecadoThe organic phase was dried over magnesium sulphate
5. 5
   Otroevaporated in vacuo

Procedimiento

N-{2-[3,4-Bis-(1-benzyl-1H-tetrazol-5-yl)phenoxy]phenyl}acetamide (40 mg, 0.07 mmol) was dissolved in ethanol (10 ml). 4N hydrochloric acid (10 ml) was added and the reaction mixture was refluxed for 15 hours. The mixture was evaporated in vacuo and redissolved in methylene chloride and 0.5 N aqueous sodium hydroxide (1:1) (20 ml). The organic phase was dried over magnesium sulphate and evaporated in vacuo to give 2-[3,4-bis-(1-benzyl-1H-tetrazol-5-yl)phenoxy]phenylamine as an oil (yield: 37 mg (100%)). 1H-NMR (CDCl3 in ppm): 3.9 (2H, broad s); 5.58 (4H, s); 6.75 (1H, d.d.); 6.85 (1H,d.d.); 6.9 (1H,d.d.); 7.0 (1H,d.d.); 7.1 (1H,d.d.); 7.2-7.4 (10H,m); 7.48 (1H,d); 7.8 (1H,d).

Fuente