Reacción #1440334

Ecuación de reacción

dioxane

compound

3-(5-(2-(2-(4-methylphenyl)-5-methyloxazol-4-yl)ethoxy)-3,4-dihydronaphthalen-1-yl)propanamide

trifluoroacetic acid

→

title compound

3-(5-(2-(2-(4-methylphenyl)-5-methyloxazol-4-yl)ethoxy)-3,4-dihydronaphthalen-1-yl)propanenitrile

Disolventes

pyridine

Condiciones de reacción

Tratamiento posterior

1. 1
   ConcentraciónThe reaction mixture was concentrated
2. 2
   workup.ADDITIONthe residue was diluted with ethyl acetate
3. 3
   LavadoThe diluted solution was washed with 1 N hydrochloric acid, water
4. 4
   Secadoa saturated saline in this order, dried with anhydrous magnesium sulfate
5. 5
   Concentraciónconcentrated
6. 6
   OtroThe residue was purified by silica gel column chromatography (hexane:ethyl acetate=4:1)

Procedimiento

To a dioxane (15 ml) solution of the compound prepared in Example 10, pyridine (363 μl) and trifluoroacetic acid (423 μl) were added, followed by stirring at room temperature for 1 hour. The reaction mixture was concentrated, and the residue was diluted with ethyl acetate. The diluted solution was washed with 1 N hydrochloric acid, water and a saturated saline in this order, dried with anhydrous magnesium sulfate, and concentrated. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=4:1) to thereby obtain the title compound (533 mg) having the following physical data.

Fuente