Reacción #1436395

ord-983194183dad44ce9811a64b4358b029

Ecuación de reacción

CC(C)(C)OC(=O)N1CC(=CCl)C[C@H]1C(=O)O
(2S,4EZ)-1-(tert-butoxycarbonyl)-4-(chloromethylene)-2-pyrrolidinecarboxylic acid
O=C(Cl)COc1ccccc1
phenoxyacetyl chloride
NCc1cccc2ccccc12
1-naphthylmethylamine
→
O=C(NCc1cccc2ccccc12)[C@@H]1CC(=CCl)CN1C(=O)COc1ccccc1
title compound
O=C(NCc1cccc2ccccc12)[C@@H]1CC(=CCl)CN1C(=O)COc1ccccc1
(2S,4EZ)-4-(chloromethylene)-N-(1-naphthylmethyl)-1-(phenoxyacetyl)-2-pyrrolidine-carboxamide

Reactantes

CC(C)(C)OC(=O)N1CC(=CCl)C[C@H]1C(=O)O
(2S,4EZ)-1-(tert-butoxycarbonyl)-4-(chloromethylene)-2-pyrrolidinecarboxylic acid
O=C(Cl)COc1ccccc1
phenoxyacetyl chloride
NCc1cccc2ccccc12
1-naphthylmethylamine

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(chloromethylene)-2-pyrrolidinecarboxylic acid, phenoxyacetyl chloride, and 1-naphthylmethylamine the title compound was obtained in 75% purity by LC/MS. MS(ESI+): m/z=435.6.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07211601B2uspto-grants-2007_05