Reacción #1436233

ord-a60bcdeb8c694a6b8b3e80f7f046f222

Ecuación de reacción

CC(C)(C)OC(=O)N1CC(=CCl)C[C@H]1C(=O)O
(2S,4EZ)-1-(tert-butoxycarbonyl)-4-(chloromethylene)-2-pyrrolidinecarboxylic acid
O=C(Cl)COc1ccc(Cl)cc1
(4-chlorophenoxy)acetyl chloride
Clc1ccc(N2CCNCC2)cc1Cl
1-(3,4-dichlorophenyl)piperazine
→
O=C([C@@H]1CC(=CCl)CN1C(=O)COc1ccc(Cl)cc1)N1CCN(c2ccc(Cl)c(Cl)c2)CC1
title compound
O=C([C@@H]1CC(=CCl)CN1C(=O)COc1ccc(Cl)cc1)N1CCN(c2ccc(Cl)c(Cl)c2)CC1
1-({(2S,4EZ)-4-(chloromethylene)-1-[(4-chlorophenoxy)acetyl]pyrrolidinyl}-carbonyl)-4-(3,4-dichlorophenyl)piperazine

Reactantes

CC(C)(C)OC(=O)N1CC(=CCl)C[C@H]1C(=O)O
(2S,4EZ)-1-(tert-butoxycarbonyl)-4-(chloromethylene)-2-pyrrolidinecarboxylic acid
O=C(Cl)COc1ccc(Cl)cc1
(4-chlorophenoxy)acetyl chloride
Clc1ccc(N2CCNCC2)cc1Cl
1-(3,4-dichlorophenyl)piperazine

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(chloromethylene)-2-pyrrolidinecarboxylic acid, (4-chlorophenoxy)acetyl chloride, and 1-(3,4-dichlorophenyl)piperazine the title compound was obtained in 64% purity by LC/MS. MS(ESI+): m/z=543.6.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07211601B2uspto-grants-2007_05