Reacción #1436180

Ecuación de reacción

ammonium chloride

Chloromethyltriphenylphosphonium iodide

potassium tert-butoxide

1-tert-butyl 2-methyl (2S)-4-oxo-1,2-pyrrolidinedicarboxylate

→

desired product

Rendimiento 93.0%

1-tert-butyl 2-methyl (2S,4EZ)-4-(chloromethylene)-1,2-pyrrolidinedicarboxylate

Rendimiento 93.0%

Disolventes

diethyl ether

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe reaction was then cooled to 0° C.
2. 2
   TemperaturaThe reaction was then warmed to room temperature
3. 3
   workup.STIRRINGstirred for 30 minutes
4. 4
   OtroThe organic layer was removed in vacuo
5. 5
   Lavadothe aqueous washed with diethyl ether (3×5 ml)
6. 6
   SecadoThe combined organic layers were dried with brine and magnesium sulfate
7. 7
   Filtraciónbefore filtering
8. 8
   Otroremoval of solvent

Procedimiento

Chloromethyltriphenylphosphonium iodide (270 mg, 0.62 mmol) was added to a solution of potassium tert-butoxide (67 mg, 0.59 mmol) in anhydrous diethyl ether (5 ml) under nitrogen and the resulting bright yellow mixture stirred for 30 minutes at ambient temperature. The reaction was then cooled to 0° C. and a solution of 1-tert-butyl 2-methyl (2S)-4-oxo-1,2-pyrrolidinedicarboxylate (100 mg, 0.41 mmol in 2 ml anhydrous diethyl ether) was added dropwise. The reaction was then warmed to room temperature and stirred for 30 minutes before adding saturated aqueous ammonium chloride solution (0.5 ml). The organic layer was removed in vacuo, and the aqueous washed with diethyl ether (3×5 ml). The combined organic layers were dried with brine and magnesium sulfate before filtering and removal of solvent. The desired product was isolated by silica gel chromatography, eluting with 15% ethyl acetate in hexanes to give 105 mg (93% yield) as a off-white wax.

Fuente