Reacción #1435734

Ecuación de reacción

5,7-dichloro-6-(2,4,6-trifluorophenyl)imidazo[1,2-a]pyrimidine

di-n-propylamine

chloroform

→

5-(di-n-propylamino)-6-(2,4,6-trifluorophenyl)-7-chloroimidazo[1,2-a]pyrimidine

Rendimiento 83.1%

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturato cool
2. 2
   SecadoThe separated organic layer was dried over sodium sulfate
3. 3
   Concentraciónconcentrated

Procedimiento

A mixture of 0.095 g of 5,7-dichloro-6-(2,4,6-trifluorophenyl)imidazo[1,2-a]pyrimidine and 0.12 g of di-n-propylamine was heated at 80° C. for one hour. The reaction mixture was allowed to cool, and chloroform and water were added thereto. The separated organic layer was dried over sodium sulfate and concentrated. The residue was subjected to silica gel column chromatography to give 0.095 g of 5-(di-n-propylamino)-6-(2,4,6-trifluorophenyl)-7-chloroimidazo[1,2-a]pyrimidine.

Fuente