Reacción #1435732

Ecuación de reacción

5-hydroxy-6-(2-chloro-6-fluorophenyl)-7-methylimidazo[1,2-a]pyrimidine

N,N-diethylaniline

phosphorus oxychloride

→

5-chloro-6-(2-chloro-6-fluorophenyl)-7-methylimidazo[1,2-a]pyrimidine

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturawas refluxed
2. 2
   Temperaturaunder heating for 26 hours
3. 3
   ConcentraciónThe reaction mixture was concentrated
4. 4
   workup.ADDITIONdichloromethane and aqueous saturated sodium bicarbonate solution were added to the residue
5. 5
   LavadoThe separated organic layer was washed with water
6. 6
   Secadodried over sodium sulfate
7. 7
   Concentraciónconcentrated

Procedimiento

A mixture of 0.16 g of 5-hydroxy-6-(2-chloro-6-fluorophenyl)-7-methylimidazo[1,2-a]pyrimidine, 0.20 g of N,N-diethylaniline and 2 ml of phosphorus oxychloride was refluxed under heating for 26 hours. The reaction mixture was concentrated, and dichloromethane and aqueous saturated sodium bicarbonate solution were added to the residue. The separated organic layer was washed with water, dried over sodium sulfate and concentrated. The residue was subjected to silica gel chromatography to give 45mg of 5-chloro-6-(2-chloro-6-fluorophenyl)-7-methylimidazo[1,2-a]pyrimidine.

Fuente