Reacción #1435691

Ecuación de reacción

trifluoroacetic acid ethyl ester

1,4,7-triazaheptane

→

1,7-Bis(trifluoroacetyl)-1,4,7-triazaheptane

Disolventes

tetrahydrofuran

Condiciones de reacción

Tratamiento posterior

1. 1
   Concentraciónconcentrated by evaporation in a vacuum
2. 2
   OtroThe remaining oil is crystallized from hexane

Procedimiento

113.3 g (790 mmol) of trifluoroacetic acid ethyl ester is added in drops to a solution consisting of 41.14 g (390 mmol) of 1,4,7-triazaheptane in 350 ml of tetrahydrofuran at 80° C. and under nitrogen. It is allowed to stir overnight at room temperature, concentrated by evaporation in a vacuum. The remaining oil is crystallized from hexane.

Fuente