Reacción #1382

Ecuación de reacción

methyl 2-methyl-3-fluoro-4,6-dibromobenzoate

ethanol

sodium hydroxide

→

2-methyl-3-fluoro-4,6-dibromobenzoic acid

Rendimiento 84.4%

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturathe mixture is refluxed for 2 hours
2. 2
   TemperaturaAfter cooling
3. 3
   Extracciónextracted with diethyl ether
4. 4
   Extracciónextracted with diethyl ether
5. 5
   ConcentraciónThe solvent is concentrated

Procedimiento

To methyl 2-methyl-3-fluoro-4,6-dibromobenzoate (75.5 g) are added ethanol (460 ml) and 10% aqueous solution of sodium hydroxide (460 ml) and the mixture is refluxed for 2 hours. After cooling, the reaction mixture is diluted with water and extracted with diethyl ether. The aqueous layer is made acidic with conc. hydrochloric acid and extracted with diethyl ether. The solvent is concentrated to give 2-methyl-3-fluoro-4,6-dibromobenzoic acid (61 g), m.p. 144°-146° C.

Fuente