Reacción #1381972

ord-fd57093c79ee4f8898e8153fc012c190

Ecuación de reacción

Cl.Clc1ccc2nc(N3CCNCC3)ccc2c1
6-chloro-2-piperazin-1-yl-quinoline hydrochloride
CCOC(C)=O
ethyl acetate
CC(C)Oc1ccc(S(C)(=O)=O)cc1C(=O)O
2-isopropoxy-5-methanesulfonyl-benzoic acid
→
CC(C)Oc1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2ccc3cc(Cl)ccc3n2)CC1
title compound
CC(C)Oc1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2ccc3cc(Cl)ccc3n2)CC1
[4-(6-Chloro-quinolin-2-yl)-piperazin-1-yl]-(2-isopropoxy-5-methanesulfonyl-phenyl)-methanone

Reactantes

—
example 1.1 ( b )
Cl.Clc1ccc2nc(N3CCNCC3)ccc2c1
6-chloro-2-piperazin-1-yl-quinoline hydrochloride
CCOC(C)=O
ethyl acetate
CC(C)Oc1ccc(S(C)(=O)=O)cc1C(=O)O
2-isopropoxy-5-methanesulfonyl-benzoic acid

Reactivos

Ninguno

Disolventes

CC#N
acetonitrile

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

Prepared in analogy to example 1.1 (b) from 6-chloro-2-piperazin-1-yl-quinoline hydrochloride and 2-isopropoxy-5-methanesulfonyl-benzoic acid (example 2.2) in acetonitrile. Chromatography (SiO2; ethyl acetate) yields the title compound as a yellowish foam.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07241761B2uspto-grants-2007_07