Reacción #1381

Ecuación de reacción

Methyl 2-methyl-3-nitrobenzoate

→

methyl 2-methyl-3-aminobenzoate

Rendimiento 101.6%

Disolventes

acetic acid

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroat room temperature
2. 2
   Filtraciónthe catalyst is filtered off
3. 3
   ConcentraciónThe reaction mixture is concentrated
4. 4
   workup.ADDITIONis added water
5. 5
   Extracciónfollowed by extraction with dichloromethane
6. 6
   ConcentraciónThe solvent is concentrated

Procedimiento

Methyl 2-methyl-3-nitrobenzoate (10.0 g) is dissolved in acetic acid (50 ml) and thereto 5% Pd-C (1 g) is added to carry out catalytic reduction at room temperature under 1 atm. After 1.5 hours, the catalyst is filtered off. The reaction mixture is concentrated, and thereto is added water, and the mixture is made alkaline with potassium carbonate, followed by extraction with dichloromethane. The solvent is concentrated to give methyl 2-methyl-3-aminobenzoate (8.6 g).

Fuente