Reacción #1375813

Ecuación de reacción

methyl 4-tri-n-butylstannylbenzoate

KOH

acetic acid

water

→

title compound

Rendimiento 90.3%

4-Tri-n-butylstannylbenzoic acid

Rendimiento 90.3%

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe resulting solution was refluxed for 2 hours
2. 2
   TemperaturaThe solution was cooled
3. 3
   ExtracciónThe solution was then extracted with diethyl ether (80 ml)
4. 4
   LavadoThe ether phase was washed with water (30 ml)
5. 5
   Secadodried over MgSO4 (5 g)
6. 6
   Filtraciónfiltered
7. 7
   Otroevaporated under reduced pressure

Procedimiento

To a solution of methyl 4-tri-n-butylstannylbenzoate (3.0 g, 7 mmol) in absolute ethanol (60 ml) was added 0.25 g KOH (9 mmol). The resulting solution was refluxed for 2 hours. The solution was cooled and poured into an ice-cold solution of acetic acid (0.64 g, 10.6 mmol) and water (100 ml). The solution was then extracted with diethyl ether (80 ml). The ether phase was washed with water (30 ml), dried over MgSO4 (5 g), filtered and evaporated under reduced pressure to afford 2.6 g (88%) of the title compound. This material was used without further purification.

Fuente